Clinical efficacy in cats

The effectiveness of Nocita™ (bupivacaine liposome injectable suspension) in providing prolonged regional postoperative analgesia was evaluated in a randomized, prospective, blinded, placebo-controlled, multicenter field study in client-owned cats undergoing feline onychectomy.¹

Study design:                                    

241 client-owned cats undergoing forelimb onychectomy  

5.3 mg/kg/forelimb administered once prior to surgery as a 4-point nerve block

Pain Assessments:*

  • Post-operative pain assessed at multiple time points through 72 hours following administration
  • Success defined as no pain intervention       

*Pain intervention = rescue analgesia or score of ≥6 on Modified UNESP-Botucatu Multidimensional Composite Pain (Brondani) Scale            


Nocita was proven to provide up to 72 hours of regional postoperative analgesia following feline onychectomy:1                                        

  • Percent of treatment success for the Nocita- treated group was statistically significantly greater than the placebo-treated group over 0-24 hours                                           
  • Greater percent successes through 48 and 72 hours support effective use of Nocita for up to 72 hours of analgesia

Safety in cats

Nocita demonstrated safety as a peripheral nerve block in cats undergoing onychectomy.1


 For single-dose infiltration into the surgical site to provide local postoperative analgesia for cranial cruciate ligament surgery in dogs. For use as a peripheral nerve block to provide regional postoperative analgesia following onychectomy in cats. 

Important Safety Information: 

Nocita is for use in dogs and cats only. Do not administer concurrently with bupivacaine HCl, lidocaine or other amide local anesthetics. The safe use of Nocita in dogs and cats with cardiac disease or with hepatic or renal impairment has not been evaluated. The safe use in dogs or cats younger than 5 months of age, that are pregnant, lactating, or intended for breeding has not been evaluated. The most common adverse reactions in dogs were discharge from incision, incisional inflammation and vomiting. The most common adverse reactions in cats were elevated body temperature and infection or chewing/licking at the surgical site. Click here for full prescribing information

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