BRD is an RBD (really big deal) and a big challenge. Commonly known as shipping fever or pneumonia, BRD is one of the most pervasive diseases in the cattle industry. Learn how you can prevent, control and treat BRD with Elanco.

Breathe Easier. We've got you covered.

Unpredictable weather, nutritional challenges and transportation stress on your herd may not always be in the realm of your control. But the cost to cattle producers — about $1 billion annually1 — doesn't go unnoticed. With our portfolio that is 40 years in the making, you can choose what tools you use to control and treat BRD in your herd.

Prevent BRD

BRD-causing pathogens are both viral and bacterial. Vaccination that protects against both is an important part of a BRD-prevention strategy that prepares each animal's immune system. 

Elanco BRD vaccines help protect against the leading causes of BRD so cattle stay healthy and productive.


NUPLURA PH gives the fastest protection in as few as 10 days against Mannheimia haemolytica — the bacterial pathogen responsible for most cases of BRD.² NUPLURA PH+ combines the protection of NUPLURA PH and Titanium® in one vaccine, giving herds fast, smooth and powerful protection against Mannheimia haemolytica, BVD Type 1 and 2 and IBR — leading causes of BRD.


Provides important protection as a modified live virus (MLV) vaccine against up to 10 respiratory and reproductive pathogens. Used as the foundation of a vaccine program for lifetime immunity, trust Titanium to set your herd up for protection without post-vaccinal stress.*³,⁴

Vira Shield®

Delivers Control Without Complication® against up to 13 respiratory and reproductive pathogens. Stress less with Vira Shield as it doesn’t negatively impact reproductive rates so you can see more calves and fewer open animals.⁵

Master Guard®

Offers a unique combination of protection against 11 respiratory and reproductive pathogens through both inactivated and MLV antigens to provide respiratory and reproductive protection for your herd — including pregnant cows.

Treat and Control BRD

Even with excellent management, genetics and vaccination, antibiotics may be necessary for BRD treatment and control. Antibiotic selection is an important choice because BRD has a broad range of causative pathogens.

That's why producers can count on the broad Elanco antibiotic portfolio. With a variety of products for control and treatment, producers can choose from multiple modes of action to select the right product, at the right time, to help keep their cattle productive and healthy. 

Increxxa™ (tulathromycin injection)

The macrolide antibiotic you can trust to help your cattle breathe easier while balancing your budget.

Baytril® 100 (enrofloxacin)

Delivers effective therapeutic drug concentrations with a single dose and a unique bactericidal mode of action (MOA) with broad-spectrum activity.

Micotil® (tilmicosin injection)

A proven, long-lasting BRD treatment that offers an effective, flexible dose range for both metaphylaxis and individual pull-and-treat therapy.

Loncor® 300 (florfenicol)

Treats and controls BRD in high-risk cattle as well as treats foot rot in beef and non-lactating dairy cattle.

Tylan® Injection

Treats BRD in high-risk cattle as well as treats foot rot in beef and non-lactating dairy cattle.

Zelnate® DNA Immunostimulant

The first licensed immunostimulant that aids in the treatment of BRD due to Mannheimia haemolytica, the leading cause of BRD.

Elanco instituted a multi-faceted eight-point plan to help increase responsible antibiotic stewardship, reduce the need for antibiotics and replace them with alternatives. Learn More.

Micotil® (tilmicosin injection) is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni, and for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica.


Before using this product, it is important to read the entire product insert, including the boxed human warning. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Injection of this drug in humans has been associated with fatalities. Keep out of reach of children. Do not use in automatically powered syringes. Exercise extreme caution to avoid accidental self-injection. In case of human injection, consult a physician immediately and apply ice or cold pack to injection site while avoiding direct contact with the skin. Avoid contact with eyes. Always use proper drug handling procedures to avoid accidental self injection. Consult your veterinarian on the safe handling and use of all injectable products prior to administration. For use in cattle or sheep only. Inject subcutaneously. Injection of this antibiotic has been shown to be fatal in swine and non-human primates, and may be fatal in horses and goats. Do not use in female dairy cattle 20 months of age or older. Use in lactating dairy cattle or sheep may cause milk residues. The following adverse reactions have been reported: in cattle: injection site swelling and inflammation, lameness, collapse, anaphylaxis/anaphylactoid reactions, decreased food and water consumption, and death. Micotil has a preslaughter withdrawal time of 42 days.

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Zelnate is based on technology developed by Juvaris BioTherapeutics and is patent protected. Animal health applications are being developed exclusively under the rights of Elanco and are protected by patents. 

Increxxa, Loncor, Master Guard, Micotil, Nuplura, Titanium, Tylan, Vira Shield, Zelnate, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other product names are trademarks of their respective owners.

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